THE BEST SIDE OF PKRRATING

The activated enzyme then phosphorylates its important substrate, the translational initiation factor eIF2α. The ensuing translational arrest blocks viral replication. PKR belongs to a conserved family members of four protein kinases (PKR, PERK, GCN2, HRI) that every one phosphorylate eIF2α in reaction to various stimuli12, triggering the built-i